Aphrodite w-3 Page 28

  Like Kransten, she began in sales, for a door-to-door cosmetics company. It didn't take her long to move into the home office in Nashville, Tennessee. She became head of Sales, then head of Sales and Marketing, and then she was made president. The company was bought by a larger cosmetics firm, based in Atlanta, and Louise was brought along for the ride. By the time she met Kransten, she was running the larger company and Time magazine was writing about her as the most powerful woman executive in the country under the age of forty. When she met Douglas Kransten, it was the perfect merger. She spent their first two dates telling him about her vision for beautifying the world. He spent the next two dates explaining that his mission was to keep America young. Four months later, they were married.

  As early as 1970, Kransten had steered his company to become one of the first of its kind to turn its energies toward genetic engineering. They were at the forefront, too, in the extraordinary competition to map the human genome. But while others thought that the gold rush would be in the storage and sale of genomic information, Kransten knew, very early on, that it wasn't the information that was of value. Kransten staked his fortune on what he knew best: pharmaceuticals. He gambled his future on the practical applications that were now possible with the genomic miracle. And his gamble proved correct. By the mid-1980s Kransten was the third largest pharmaceutical company in the world. He had managed to buy Louise Marshall's company and they merged philosophies, products, and bank accounts. They were worth several billion dollars.

  In 1986, the U.S. economy was starting to fail. At the same time, KranMar, as the new company was now called, and several other of the top pharmaceutical and research companies were spending hundreds of millions of dollars in the attempt to eradicate disease. They all knew that the ultimate goal was a cure for cancer. If their research could provide that, there were hundreds of billions of dollars to be made.

  In September of 1986, Doug Kransten and two other pharmaceutical titans, Ronald Mayberry, CEO of MayDay, Inc., and Patrick Arnold, chairman of Selwick International, were called to Washington, D.C. There were several people high up in the administration, not the president or the vice-president, but people who made it clear that they were representing the views of both elected officials. It was explained to Kransten, Mayberry, and Arnold that the government was extremely worried about their companies' activities. They were developing products and drugs that could very possibly extend people's lives another ten, twenty, even thirty years. With the developments that were certain to come in stem-cell research and the final mapping of the genome, it was not inconceivable that men and women would routinely live to be a hundred and twenty years old. The pharmaceutical executives agreed that it was certainly possible, but they didn't see it happening in the immediate future. The government officials stated their position a little more clearly: It was not to happen at all. Not now, not in the immediate future, not in any future that was foreseeable.

  The executives were stunned. And they demanded an explanation.

  They were given one. And it was simple and obvious: The world economy could not handle it.

  If the population kept exploding and people's lives were extended, the U.S. government-all governments, in fact-could not afford to keep its infrastructure functioning. The Social Security system, which was based on the premise that each generation, as it aged, would be supported by the next working generation, could not possibly survive. It was already at the point where the post-baby boomer generation, the so-called Gen X, would be working harder and harder-and longer and longer-to support the huge throngs of nonworking elderly among the boomers. We were already near the breaking point. Further medical breakthroughs would bankrupt the country and the rest of the world.

  The three CEOs understood the problem. They also understood that such an agreement was antithetical to the entire capitalistic system. Not to mention their dedication to science.

  A deal was made. Science went by the wayside, but capitalism was triumphant.

  The companies-along with seven other pharmaceutical companies that, over the following twelve-month period, were brought into the bargain-were allowed to continue with their research and development. But there were specified limits. Cosmetic products could be developed-fat reducers and antiwrinkle creams-and even certain drugs and medicines could be elaborated upon. Sex enhancers would be worth billions, and the companies were encouraged to strike out in that area. In exchange for these limits, certain allowances would be made. FDA restrictions would be relaxed. Products would be let through that might not have been allowed before. They would have the opportunity to test products on a wide-ranging-and unsuspecting-public. There was a lot of money to be made if normal regulations were eased or even erased altogether.

  A lot of money.

  There was one other catch, of course: This arrangement had to be secret. Absolutely, one hundred percent hidden from the public. Yes, people cared about the economy. But if word got out that the administration-any administration-was bartering with the length of life itself, well, it went without saying what would happen. It would be very difficult for any politician to win an election if it were known that he was lopping twenty years off the lives of his constituents.

  The deal was done.

  And it continued for years.

  From one administration to the next. It didn't matter which party; they were all politicians. They could all see the future and the same political dangers. It was a matter of their own survival.

  Brewster Ford was the link, Manwaring explained. His financial acumen and his ability to interpret the world economy were legendary and near infallible. His agenda was never political, which was why he was trusted by both parties. His focus was strictly, unrelentingly, on the economic picture-past, present, and future. When Ford spoke about money, the whole world listened.

  Some administrations were easier to convince than others, Manwaring said. Some were cynical and receptive to anything that benefited big business, no matter the consequences. Some expressed horror at the deal but overcame their moral indignation when the political consequences became so clear. Some presidents were more detail oriented and more involved in policy decisions than others. Some didn't want to know the specifics. One insisted on an elaborate, private presentation from Ford. But the previous three presidents had ultimately capitulated. Politics took a backseat when it came to preserving their own positions of power.

  The current administration was easy. Manwaring believed that the president had no idea about the bond between the pharmaceutical companies and the government. But it didn't matter. There had, over the past several years, been a tremendous swell against science from the religious right. Even Darwinism was under attack in several states. The president tended to share these antediluvian beliefs but, more important than embracing and spreading core philosophies, he wanted the vote from that constituency, many of whom had previously become disenfranchised from the party. His advisers-those who were aware of the backroom dealing-only had to steer him in the direction his instincts were already leading him. The president basically killed off stem-cell research in America without even being aware that he was continuing the fifteen-year-old contract. He simply was allowed to believe that he was doing the moral and politically expedient thing. There was no problem keeping the arrangement going.

  And then two things occurred.

  First, he, Manwaring, was named secretary of Health and Human Services. He was an old friend of this president and he liked him very much, even if he did not always share the man's black-and-white view of the world.

  Several months after he was approved by Congress, Manwaring was asked to come to a meeting at the White House. There he met with the president's chief of staff and Brewster Ford. To his surprise, his predecessor-a liberal, from the other party-was also present. As was Chase Welles, the new head of the Food and Drug Administration. At this meeting, the arrangement with the pharmaceutical companies was explained to him and to Welles. Ford laid out the entire potentially dev
astating scenario. Welles seemed to have no problem with any of it. But it disturbed Manwaring. His predecessor as secretary saw his resistance and, in answer to one of Manwaring's questions about the real necessity for the pact, said, "Necessary? Here's how necessary this is. Forget about the government trying to ban cigarettes. Pretty soon we'll have to make smoking obligatory, just so we can kill off a few billion people."

  Manwaring was deeply troubled, morally and politically, by the implications of what he heard. But he accepted it. He understood that he was a crucial piece in this puzzle because so many of his decisions, so much of his work with the FDA, would be directly affected by what he was hearing. He weighed the pros and cons, listened to the arguments- all from people he respected and trusted-and he decided that he could live with such an arrangement. He decided that he was dealing with two evils, but one was definitely greater and more damaging to the world as a whole.

  But things changed.

  Accepting something in theory was quite different from accepting it in practice. The FDA, led by Chase Welles, approved several drugs and supplements that caused severe adverse effects. Several deaths, yes, but also many recorded cases of liver damage and heart failure. An anti-depressant, released by MayDay, drove eleven people to suicide over a three-month period. A drug that was widely used in the treatment of breast cancer, released by Selwick, damaged kidneys and caused strokes. Still, Manwaring told Justin and Deena, he remained silent. The logic, he kept telling himself, was the same that applied during wartime. It was acceptable to sacrifice the few to save the majority.

  After September 11, however, he clashed with Kransten. KranMar held the patent for a drug that was extremely effective against anthrax. They did not have the facilities to make enough of it-or at least enough to satisfy a public that was panicking and desperately needed reassurance. During the first few months after the World Trade Center attacks, it was nearly impossible to determine potential threats. No one knew what the terrorists were capable of or willing to do. There was a legitimate fear that anthrax could be used, via mail or via the water supply, to wipe out millions of people. Manwaring lifted KranMar's patent, allowing a Canadian company to make a generic version of the drug. The action enabled millions more people to have access to it. But Manwaring was called into the Oval Office and told, by the president himself, that this was never to happen again. Manwaring argued-never telling the president the truth behind the pressure that was being placed on him, strictly explaining the need for such actions-but his arguments did no good. It became clear to him that the lesser of two evils could quickly become, and might already have become, the greater danger.

  Three months after that, KranMar introduced a pill that was marketed as one that caused fat to bypass the body's system entirely. It was an extraordinary success from the first day the television advertisements ran. Within a year, twenty-eight people had died after using the pills. Manwaring ordered production held up so more testing could be done. He had an extraordinary clash with Chase Welles, who publicly hinted that Manwaring was being bribed by rival pharmaceutical companies who were developing similar products. The White House did not back Manwaring, instead siding with the Food and Drug Administration chief. False information was disseminated to the media and Manwaring found his integrity and judgment attacked from both the left and the right. Still he was a good soldier and said nothing. He kept trying to look at the bigger picture and the ramifications of going public with what he knew.

  Then he was contacted by Maura Greer.

  At this point in the story, Helen Roag stepped forward. She had changed into a pair of khaki pants and a cotton blouse. Manwaring still wore his robe.

  Helen said that she had been working at the Aker Institute, a subsidiary of KranMar, for several years. She had a research background but was asked to assume more of a managerial role than she had anticipated. She was stunned at the raises she was given, so she rarely argued about the responsibilities they were assigning to her. She knew she was being paid two, three, even four times the amount someone in her position should have been paid.

  At some point, she was asked to have lunch with Douglas Kransten himself. She was dumbfounded but, no question about it, flattered. He praised her work to the skies, and then, midway through the meal, he began to talk to her about a special assignment. One that he said was a little tricky. There was some risk involved, he said, but its scientific value was incalculable. He said that as early as 1970, he had become convinced that human growth hormones were the key to eradicating many of the problems that struck the human body as it aged. He'd had a team of scientists working on it since that time. Kransten told Helen that they'd done some experiments around the country, beginning as early as 1972. They'd had astonishing success with some of their subjects. He showed her that, in the northeast region alone, eighteen subjects-ten males, eight females-had lived to be over one hundred years old. Kransten was convinced-no, more than convinced, absolutely certain-that his people had discovered a way to slow down the aging process.

  He showed her some of the experimentation. Groups of people had been fed and injected with various combinations of such supplements as L-arginine and glycine and L-ornithine and L-glutamine. There were some miraculous results at first. Wounds healed, immune responses to bacteria, viruses, and tumor cells improved. The loss of skeletal muscle diminished, as did fatigue. Gradually, the results became even more miraculous. Many of those who had participated in the experiments were living longer. The aging process had been delayed, in some cases substantially. Helen had looked at the data, agreed that it was interesting and impressive, but she disagreed with him that the proof was absolute.

  It's not ready to be released to the public, he told her. There are problems. But the problems are close to being solved.

  We are on the verge of doubling the life span of the normal human being, Kransten told her. And there is absolute, undeniable proof.

  She asked to see it, but he just shook his head. The proof is overseas, he told her. Someday she would see it. But not yet.

  He told her what he wanted her to do and she agreed. The money he added to her salary was the main inducement, but so was the scientific value of his experiment. Everything had to be done in strict secrecy. They were doing a good thing, Kransten said, but the government did not agree. They will never allow this, he told her, until it's absolutely safe and proven. But it was a Catch-22. The only way to reach that stage was to continue with the forbidden experimentation. She accepted his logic.

  She was assigned to half of the eighteen survivors of the early 1970s testing. She saw each of them every three months. If they needed her they could contact her via Growth Industries, a shell corporation set up only to distance KranMar from the subjects. All of the elderly subjects were living at different old-age homes. Their expenses were fully paid. They were given anything they needed to make their lives easier and pleasurable. When she saw them, she not only collected new data, she was charged with giving them their hormone injections. The experiments had continued all these years. What was being injected varied, as testing and information had gotten so much more sophisticated over this period. But the ones who survived continued to survive. Several of them outlived the managers of their homes. She had one subject, in Vermont, who was now 122 years old-and healthy and vital.

  But the more involved she became, the more misgivings she began to have.

  The original series of experiments in 1972 was given the appellation Aphrodite, named after the ancient Greek goddess of love and beauty. They were conducted in upstate New York, near Binghamton, in a private hospital owned by Kransten. As Helen learned more about them- from discussions with her subjects and, gradually, from the files she either had access to or managed to steal-she began to realize the extent of the damage that had been done. Yes, there were eighteen survivors of the initial experiments. But over a hundred subjects had died as a direct result of the treatments.

  Then something happened that forced her into action. She
had noticed that Kransten and his wife were spending much time in Europe, particularly at their house in England. She arranged a meeting with one of Kransten's researchers, a young and attractive man named Lonnie Parker, who had been spending time in the England lab. It wasn't anything out of the ordinary; it was part of her job to remain current on research matters. But Dr. Parker was-and here Helen hesitated, had the grace to blush slightly, before continuing on with her story-interested in her. Romantically interested. Well-and Helen blushed again-sexually interested. She saw him several times. He would only give her minor details about the experiments taking place in England. She learned that the main lab was actually in Kransten's home, which she hadn't realized. But, although she sensed he wanted to talk, he shied away from revealing anything substantive. On their third date, however, he had too many margaritas and he began to talk about what he'd seen in England. He still wouldn't come out and tell her exactly what was going on, but he used a strong word for a scientist. He used the word "ungodly" when he described the program known as Aphrodite.

  The next morning, when Lonnie Parker sobered up, he begged her not to repeat anything he'd said. He told her it would be dangerous for her if any rumors were traced back to her. "Dangerous?" she asked, and she remembered laughing. Parker didn't laugh. He told her he was going to resign. That he was not able to deal with what he had seen and done over the past few months. He was going to resign that very day.